Goldfinch is singularly focused on discovering and developing precision therapies for patients with kidney disease.

Chronic kidney disease is a driver of mortality across age, race, and stage of disease progression, affecting over 1 in 9 people worldwide. It has emerged as a global epidemic and growing problem that places an enormous social and economic burden on patients, their families, and society.

Advances in kidney transplantation and dialysis over half a century ago extended life for patients with kidney failure, yet the current standard of care for patients with kidney disease remains inadequate, and there is an urgent need for new treatment options.

Recent breakthroughs in genetics and biology have generated an unparalleled understanding of the biological pathways that drive kidney disease. Goldfinch is uniquely positioned to translate these discoveries into new therapies that target the molecular causes of kidney disease.


The burden of kidney disease for patients and society





Goldfinch brings together experts in the field and experienced leaders with a shared mission to pioneer new treatments for patients with kidney disease.


Anthony Johnson, M.D.

Chief Executive Officer

Michael Broxson

Chief Business and Operating Officer

Jean-Christophe Harmange, Ph.D.

Senior Vice President of Drug Discovery

Peter Mundel, M.D.

Senior Vice President of Biology

Maria Beconi, Ph.D.

Vice President of Pharmacology and Non Clinical Development

Curtis Demick

Vice President of Human Resources

Thomas Tibbitts, Ph.D.

Vice President of Computational Discovery

Liron Walsh, M.D.

Vice President of Translational and Clinical Nephrology

Thomas Martz

Director of Corporate Development


Our Founders and Advisors are world-renowned scientists and clinicians at the forefront of kidney biology, genetics, and genomics.

Joseph Bonventre, M.D., Ph.D.

Harvard Medical School, MIT, Brigham and Women's Hospital

Anna Greka, M.D., Ph.D.

The Broad Institute, Harvard Medical School, Brigham and Women’s Hospital

Friedhelm Hildebrandt, M.D.

Harvard Medical School, Boston Children's Hospital

Daniel MacArthur, Ph.D.

The Broad Institute, Harvard Medical School, Massachusetts General Hospital

Peter Mundel, M.D.

Goldfinch Bio

Stefan Somlo, M.D.

Yale School of Medicine


Abbie Celniker, Ph.D.

Chairwoman of Goldfinch Bio and Partner, Third Rock Ventures

Louis Brenner, M.D.

President and Chief Operating Officer, Allena Pharmaceuticals

Neil Exter

Partner, Third Rock Ventures

Anthony Johnson, M.D.

Chief Executive Officer





Goldfinch is integrating breakthroughs in kidney genetics and biology to identify new therapeutic targets and advance first-in-class drug candidates to treat patients with kidney disease.


Goldfinch’s Product Engine will industrialize the integration of genetics and kidney biology and confer a differentiated ability to identify, validate, and pursue novel therapeutic targets for kidney disease.





Goldfinch’s therapeutic programs are underscored by strong genetic validation and a deep familiarity of the biological pathways that cause disease. Our initial efforts are focused on focal segmental glomerulosclerosis (FSGS) and polycystic kidney disease (PKD).



Focal Segmental Glomerulosclerosis (FSGS), a rare kidney disorder, is a histopathologic diagnosis characterized by severe scarring of the kidney's filtering units, or glomeruli, leading to an excess of essential proteins spilling into the urine, called proteinuria. FSGS is a leading cause of kidney failure, and patients with diagnosed FSGS are at increased risk of heart attack, stroke and premature death.

There are currently no FDA approved treatments for FSGS. Existing treatments are non-specific, do not alter the progression of disease and carry significant toxicities.

Goldfinch is leading the charge to develop treatments targeting the molecular causes of FSGS to drastically improve the lives of patients suffering from this devastating, life-shortening condition.



Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common single gene diseases, affecting more than 600,000 people in the US and 12 million worldwide. The disease is passed on from parent to child, with each child of an affected parent having a 1-in-2 chance of inheriting the disorder, which does not skip generations.

ADPKD patients develop fluid filled cysts in both kidneys that increase in number and size over time, culminating in end stage kidney disease in half of affected individuals by middle age. ADPKD commonly causes liver cysts which arise from bile ducts and can sometimes grow large enough to cause symptoms as well. In the United States, 1 in 20 individuals either on dialysis or with a kidney transplant has ADPKD.

There are no FDA approved therapies specifically targeting ADPKD and no means by which to alter the course of the disease.

Goldfinch is leveraging scientific discoveries based on the known genes that cause ADPKD to discover treatments to alter the course of ADPKD and drastically improve the lives of patients suffering from this chronic and debilitating disease.





It is the patients with kidney disease who will lead us to the understanding of pathways and targets that will drive transformative drug development. To accomplish this, we will partner with patients to build the world’s most comprehensive registry of individuals with molecularly defined kidney disease.

Goldfinch is assembling a database of genetic, genomic and clinical information from consented patients who have provided thousands of DNA samples and anonymized clinical records. Building off of the studies of our founders and partners, we will deeply study DNA and correlate findings with clinical data. We will then use novel computational tools to mine for evidence of the DNA variants that increase risk for kidney disease and suggest new ways to treat and prevent it.





At Goldfinch, we are pioneering a new approach to discover and develop therapeutics for kidney disease that is unprecedented.

Where others see risk, we see opportunity to make an impact and redefine the state of care for patients with kidney disease. We recognize the importance of collaboration, and strive to work alongside patients, clinicians and other partners to empower patients and develop treatments for conditions where no approved therapies exist.

We’re looking for teammates who relish the challenge, and are compelled to leave a positive mark on the lives of colleagues and patients alike.

If this sounds like the community you want to grow with, we invite you to explore our current career opportunities below.

If you would like to be considered for an opportunity at Goldfinch Bio, please submit your CV with the title of the position in the subject line to careers@goldfinchbio.com.


Senior Research Associate, Biology

The Opportunity

The Senior Research Associate will develop, implement and execute in vivo and in vitro assays required for the advancement of high priority projects and Goldfinch Bio's Product Engine.

Major Responsibilities

  • Development and implementation of a diverse set of cellular assays used to support lead discovery
  • In partnership with scientific leadership design, execute, troubleshoot, and interpret biological experiments in support of program objectives
  • Interact and communicate results and conclusions to the biology team and cross-functional project teams

Requirements and Qualifications

  • B.S. or M.S. in cell and/or molecular biology or pharmacology
  • 3 to 5 years of industry experience
  • Experience developing cellular assays used to drive early-stage programs towards candidate selection, including miniaturization and automation of high-content imaging, as well as protein and RNA assays
  • Target validation experience with ability to assay target biology with genetic perturbation techniques such as CRISPR-Cas9 and shRNA, in addition to the construction of stable cell lines expressing genes of interest
  • Demonstrated ability to thrive in a team environment
  • Strong experimental background and a rigorous, analytical approach to problem solving
  • Familiarity with high-content phenotypic screening
  • Experience with visualization software and associated analysis of rich cellular datasets
  • Some weekend work will be required

Associate Director of Clinical Operations

The Role

The Director of Clinical Operations and Development will play a key role to manage, plan, and execute clinical development programs and studies, including creating and managing study timelines, budgets, and study management plans. Additionally, s/he will provide guidance and shared learning with and across teams throughout planning and implementation, as well as ensure clinical operational and development deliverables and timelines are met across the development program(s). This position will report to the Vice President, Clinical & Translational Nephrology.

Major Responsibilities

  • Responsible for the infrastructure build and creation of process for early-stage clinical development
  • Lead the evaluation, selection and management of Contract Research Organizations (CROs) and other external vendors to ensure successful clinical trial implementation and execution
  • Create, manage, and execute clinical operations and development programs, including study management, budget and timeline creation
  • Manage and lead CRO’s
  • Ability to build strong KOL, Principal Investigator relationships, and CRA’s with the ability to easily understand and explain complex scientific topics
  • Lead program development teams, and understand the intricacies among the different cross-functional groups, including medical affairs, HEOR, and other late-stage teams
  • Participate with clinical site staff and Investigators as appropriate to ensure optimal Sponsor-site relationships
  • Develop and ensure execution of activities outlined in various study plans (data management, safety management, and study communication plans)
  • Participate in preparation of regulatory filings (e.g. IND, pre-IND, orphan applications etc.) as needed
  • Partner with CMC/clinical supplies to provide drug supply assumptions and contribute to design and packaging of supplies for clinical trials
  • Manage all aspects of study progress from planning to close-out to assure adherence to intended timelines and achievement of study goals while ensuring quality in accordance with FDA, EMEA, GCP, and ICH guidelines
  • As appropriate, Lead, plan, and execute clinical Investigator meetings, study meetings, and vendor meetings as needed
  • Attend scientific conferences as needed

Requirements and Qualifications

  • Master’s Degree Preferred
  • 5 years of Clinical Operations experience within a sponsor company
  • Experience in All phases of development: HV, Phase 1-3, adaptive designs
  • Experience running programs in EU and the US
  • Must have rare disease experience and conducted First in Human Studies
  • Nephrology Therapeutic Area experience strongly preferred
  • Robust understanding and experience leading early-stage clinical development programs, including proof-of-concept, Phase 1, Phase 2, and through later development.
  • Must thrive working in a fast-paced, innovative environment while remaining flexible, proactive, resourceful and efficient
  • Demonstrated ability to translate strategy into action; excellent analytical skills and an ability to communicate complex issues in a simple way and to orchestrate plans to resolve issues and mitigate risks.
  • Understanding of drug development and program management from pre-IND through NDA
  • Extensive experience managing late-stage clinical programs, CROs, budgets, and timelines
  • Strong working knowledge of MS Project and developing Gantt charts
  • Experience monitoring clinical studies and conducting PSVs, SIVs, IMVs, and COVs required.
  • Management of CROs, multiple vendors, and complex protocols
  • A detailed understanding of overall strategic direction, interrelationships and business needs.
  • Proven experience in the oversight of the operational aspects of all stages of clinical studies

Principal Scientist, Biomarker and Translational Research

The Role

We’re seeking a highly motivated Principal Scientist with a strong background in disease characterization and biomarker technology to join our Pharmacology and Translational Science Department to contribute to building our pipeline for renal diseases. The successful candidate will focus on the discovery and progression of novel biomarkers and therapeutics for Goldfinch programs. Responsibilities include leading scientific research to identify, evaluate, and characterize relevant blood, urine, and kidney biomarkers that will provide useful pharmacodynamic and efficacy endpoints in preclinical and clinical settings.

Major Responsibilities

  • Develop strategy and scientific approach to identify novel diagnostic, prognostic, and pharmacodynamic biomarkers to enable scientific driven go/no go decisions for programs to assist in program progression.
  • Develop in vitro and biochemical assays to evaluate efficacy, PK/PD relationship, and novel biomarkers to characterize molecules for potential therapeutic effects.
  • Lead the identification and validation of novel biomarkers to enable scientific driven go/no go decisions for programs to assist in program progression.
  • Establish and manage external research collaborations to identify diagnostic and prognostic biomarkers for indications of interest in chronic kidney disease.
  • Participate in and lead cross-functional teams to support preclinical drug discovery and development.
  • Prepare, review and deliver high quality scientific presentations for internal/external use.
  • Commitment to help the team achieve deliverables and meet aggressive timelines.

Requirements and Qualifications

  • PhD with at least 6 years post-degree research in an industry setting.
  • Extensive hands-on experience with biomarker technology platforms, including untargeted and targeted mass spectrometry, ELISA, etc.
  • Hands-on experience in cellular and biochemical science such as standard molecular biology and protein biochemistry techniques.
  • Hands on experience in the development and validation of biomarker assays in the preclinical and clinical setting required.
  • Strong publication record and demonstrated experience conducting independent research, preferably in the field of monogenic diseases
  • Strong leadership and evidence of strategic scientific thinking.
  • Effective managerial skills and the ability to lead independent scientists with different skill sets.
  • Expertise in cutting edge assay technologies and proven assay troubleshooting skills.

Corporate Controller

The Role

We are searching for an experienced hands-on Controller to oversee all aspects of Company's accounting operations, including general ledger, SEC reporting, SOX compliance, tax, statutory reporting, accounts receivable, accounts payable, payroll, fixed assets, revenue recognition and the external audit process. The position reports to the COO and will work to drive financial strategy and execution to support the Company's growth. The Controller will also help develop the Finance department and will be an effective business partner for operating managers.

Major Responsibilities

  • Oversee the accounting close process and continuously improve processes to scale with the organization
  • Oversee and ensure accurate and timely preparation of the financial statements
  • Financial Planning and Analysis, working with CBO/COO
  • Support CBO/COO in the S-1 process in preparation for IPO.
  • Post-IPO, ensure external reporting in compliance with SEC regulations including the timely filing of Form 10-K’s, Form 10-Q’s, and proxy requirements
  • Oversee external tax advisors to ensure compliance with required tax filings and preparation of tax provisions
  • Serve as a technical accounting resource for the organization
  • Document and review technical accounting assessments and conclusions in memos for management and auditors
  • Post-IPO, oversee the Company’s SOX compliance, working to strengthen internal controls and ensure the control environment is operating effectively
  • Supervise AR, AP, payroll, fixed asset, and revenue recognition activities.
  • Oversee the accounting for equity awards
  • Act as the primary liaison to external auditors and manage all financial audits and reviews.
  • Prepare board of director and audit committee packages
  • Continue to evolve and develop an accounting department and team that is a partner to the business with an infrastructure that will support significant growth
  • Build relationships cross-functionally to foster collaboration both inside and outside of the Finance & Accounting teams
  • Lead ad hoc Finance projects as needed

Requirements and Qualifications

  • Bachelor or Master’s degree in Accounting with active CPA license required. Minimum 10+ years’ experience in accounting including recent public company experience as the controller or assistant controller
  • Proficiency with US GAAP required
  • Prior employment in a commercial biotech preferred
  • Experience implementing/maintaining accounting systems and developing reporting and analytics capabilities
  • Collaborative business partner adept in building cross-functional relationships to drive business results
  • Exhibits the highest degree of integrity and ethics
  • Excellent relationship and communications skills and the ability to quickly establish credibility
  • Strong team player that has a customer service approach and is solution oriented

Sr. Director / VP of Biology

The Role

We seek an energetic and highly driven scientist to direct our internal research and collaborations around cell biology in support of our human kidney disease production engine. A major responsibility of this role includes the biological validation of novel genetic variants identified through our Kidney Patient Registry. In addition, the successful candidate will oversee and further develop our IPSC and kidney organoid efforts.

Major Responsibilities

  • She/he will oversee our rapidly evolving portfolio, lead and develop talented scientists, and oversee the creation or adaptation of in vitro assays to enable drug discovery efforts
  • Develop/co-develop the overall strategy and lead our cell biology team in the discovery of actionable insights into kidney-disease causing genetic variants
  • Oversee the evolution our existing internal lab component (podocyte biology and kidney organoid platform), including the development, implementation and execution of in vitro and in vivo assays required for the advancement of high priority projects and Goldfinch Bio's product engine
  • Guide biological experiments in support of program objectives and translational sciences for multiple therapeutic areas

Requirements and Qualifications

  • Ph.D. or M.D. with 10 or more years industry experience, including extensive leadership experience, managing teams of scientists
  • A strong background in cell biology with an emphasis on Rho GTPase biology is strongly preferred
  • Demonstrated success with target identification and validation
  • Experience developing people and mentoring project leaders
  • Experience building biology groups in a start-up biotech / pharmaceutical company is preferred

Software Engineering Intern

The Role

Goldfinch Bio is looking for a part-time, energetic intern to help us manage some of the software engineering demands within our Computational Research department. The position will require a commitment of 10-15 hours per week for at least the next 3 months. This is a great opportunity to leverage your experience and skills to make a significant impact in the research and clinical programs at Goldfinch while gaining real-world experience in a corporate environment. The individual in this position will work closely with our Clinical department to analyze patient data along with genetic data to push towards our goal of a personalized medicine approach to treating patients with kidney disease.


  • Bioinformatics, Computer Science or similar discipline is required
  • Strong programmer with proven experience working in Python
  • Great attention to detail, and the ability to critically evaluate data that your code produces
  • The ability to communicate with non-technical personnel and the capacity to translate requests into actionable software requirements

An Ideal Candidate Has

  • Experience with data visualization in Spotfire
  • Experience with version control, preferably git
  • Experience working with Docker and/or AWS ECR
  • Experience writing unit tests in Python
  • Experience with relational and non-relational databases
  • Experience working in Amazon Web Services
  • A public code repository demonstrating experience with programming in Python

Note to Recruitment Agencies: Please do not forward any agency resumes. Goldfinch Bio is not responsible for any fees related to resumes that are unsolicited.
Equal Opportunity Employer M/F/D/V.