hero image

Careers

At Goldfinch, we are pioneering a new approach to discover and develop precision medicines for kidney disease. Where others see risk, we see opportunity to make an impact and redefine the standard of care for patients with kidney disease. We recognize the importance of collaboration, and strive to work alongside people with kidney diseases, their families and clinicians to develop innovative treatments for conditions where no approved therapies exist.

We’re looking for teammates who relish the challenge, and are compelled to leave a positive mark on the lives of colleagues and the patients we serve alike. If this sounds like the community you want to grow with, we invite you to explore our current career opportunities below.

Statistical Geneticist/Computational Genome Scientist Toggle

Job Summary

Goldfinch Bio is seeking a highly collaborative and entrepreneurial Statistical Geneticist/Computational Genome Scientist to play a central role in the continued development of the Kidney Genome Atlas (KGA) and the analysis of KGA data to drive We are looking for a highly collaborative and entrepreneurial Statistical Geneticist/Computational Genome Scientist to play a central role in the continued development of the Kidney Genome Atlas (KGA) and the analysis of KGA data to drive the discovery of novel drug targets, genomic and phenotypic biomarkers for patient stratification, and insights into the underlying molecular mechanisms of disease.  

This role will join an interdisciplinary team of geneticists, bioinformaticians, computational biologists, and software engineers working in a pioneering and collaborative environment. They will be responsible for designing and implementing robust analysis plans, building analysis workflows/pipelines, developing statistical and computational methods and performing analyses on large scale integrating data sets, and interpreting the data to help develop therapeutic hypotheses for new kidney disease treatments.

Job Responsibilities

  • Researching, adapting, and implementing cutting edge statistical genetics approaches for analyses and interpretation of large scale proprietary and publicly available genomic data.
  • Data processing and conducting QC on large scale Next Generation Sequencing datasets.
  • Developing and documenting statistical and computational genomics analysis plans using the newest methods and pipelines to interrogate whole-exome and whole-genome sequence data in combination with other genomic and phenotypic data with the KGA to enable the identification of causal genetic determinants of disease 
  • Conducting robust statistical and computational genomics analyses, for common and rare variants, genome-wide epigenetic association studies, and integrative genomic studies that incorporate sequence and expression data, analysis of RNAseq data for calculating eQTLs and differential gene expression
  • Fine mapping and locus dissection to assist in target identification, including leveraging public and proprietary genomic functional annotations and implementation of Bayesian methods for constructing credible sets of variants
  • Interpretation and communication of key findings as they relate to the goals of Goldfinch Bio’s drug discovery and development strategies
  • Providing statistical genetic and analytical insights contributing to the design of additional population based genomic studies for the continued development of the KGA
  • Curation of new public (eg UKBB) and proprietary genomic data as it is added to the KGA (e.g. ChIPseq, histone marks), including rigorous examination of batch effects
  • Providing genetics and genomics insight into target identification, nomination, and validation packages in collaboration with wet lab biologists and clinical scientists to leverage genetic findings in the design of functional validation and clinical trials.

Required Skills & Qualifications

  • Ph.D. in Statistical Genetics, Computational Biology, Human Genetics, Bioinformatics, Genetic Epidemiology, Statistics or related. Post-Doctoral training a plus.
  • Demonstrated ability to analyze next generation sequencing data, with a particular focus on whole genome and/or whole exome sequencing data and variant imputation
  • Proficiency in Python, R and Linux is required; experience with Hail is preferred
  • Experience in analysis of epigenetic data: ATAC-seq, single – cell ATAC-seq, ChIP-seq, HI-seq, visualization of binding/epigenetic loci an advantage
  • Proven ability to work independently and in a team environment
  • Excellent written and verbal communication skills and the ability to clearly articulate and explain complicated results to a senior leadership/BoD-level audience
  • Track record of peer-reviewed publications in top-tier scientific journals. Strong drive with a desire to make an impact on kidney disease
Preferred Experience in addition to the above:
  • Experience with Genome Analysis Toolkit (GATK) and/or similar variant calling pipelines
  • Experience operating in a cloud platform (Preferably AWS)
  • Experience with version control, electronic notebooks (Jupyter or other) 
  • Experience using containerization technologies (Docker or other) for reproducible research
  • Experience working with controlled access data from public repositories, such as a dbGaP and the UK BioBank
  • Experience with Mendelian Randomization and/or multi-phenotype analyses a plus
  • Experience operating in a large-scale, distributed computing environment
Senior Director, Program Team Leader Toggle

Job Summary

Goldfinch Bio seeks a highly motivated individual for the position of Senior Director, Program Team Leader for the GFB-024 program. This position will report to the Head of Program and Portfolio Management and will drive strategic management of program development activities for the company’s programs. This role is expected to be the spokesperson for the program and accountable for team deliverables. S/he will lead the program team to develop and recommend the program strategy, timing, budget, and milestones as well as to identify challenges and risks and to develop plans and actions to mitigate the identified risks. This individual will play an integral role in building efficient and collaborative cross-functional planning with functional line stakeholders to achieve effective execution of program goals. S/he will also have the opportunity to help shape the Program and Portfolio strategy for the company and mentor emerging program team leaders. This is a critical and highly visible role, making a substantial contribution to the company.

Job Responsibilities

  • Serves as a spokesperson for the program and remains accountable for team deliverables
  • Collaborates with core team members to develop and drive recommend program strategies, model scenario plans, and build presentations to support recommended courses of action
  • Regularly and proactively considers challenge points and opportunities for program acceleration
  • Effectively communicates-functional strategies associated with the program and fosters strong relationships with team members and functional lines
  • Builds operational plans for agreed program strategy, including alternative and backup scenarios.  Plan will identify all critical path activities and inter-linkages between activities. Proactively works with core team and functional line members to effectively integrate the activities cross-functionally. Ensures appropriate progress is being made against defined strategies; proactively raises issues and recommendations for resolutions.
  • Drives annual operating budget planning for the program. Together with Finance, supports the tracking of actuals to budget and communicates deviations to budget and prospectively identifies variations throughout the year.
  • Creates and manages content for key program documentation including, but not limited to, a Program Development Plan (PDP), monthly program reports and budget summaries.

Required Skills & Qualifications

  • 5-8 years of experience in the biopharmaceutical industry
  • PhD (preferred), BS/MS in a scientific discipline
  • 2-4+ years of experience leading multi-disciplinary Development Teams preferred; prior involvement on biologics development programs required
  • Project management and leadership training
  • Demonstrated effective leadership skills, has an easily recognized executive presence, and is a proven relationship builder who is effective via influence
  • Proven track record of effective interpersonal and communication skills with ability to develop strong positive relationship with senior management as well as all levels of the organization.
  • Ability to operate effectively within an entrepreneurial and science-driven company environment; self-motivated, assertive, able to inspire others, driven and hands-on with unquestionable integrity and the highest ethical standards.
  • Good corporate and matrix management skills to meet Goldfinch Bio organizational needs and to leverage resources as required to drive assigned programs forward
  • Requires a strong understanding of overall drug development strategies, spanning across all critical product development disciplines (nonclinical, clinical, CMC, RA/QA, commercial strategy and development)
  • Working knowledge of GXPs and other applicable compliance requirements.
  • Core competency for the application of traditional program management principles and practices
Senior Manager, Program Management Toggle

Job Summary

Goldfinch Bio is currently seeking a highly motivated and collaborative individual for the position of Senior Manager of Program Management to support our growing portfolio.
This position will report to the Head of Program and Portfolio Management and join cross-functional teams to provide support to the GFB-887 and GFB-024 development programs. They will collaborate with team members to develop and manage program timelines, product development plans, budgets, and milestones as well as proactively identify program risks and mitigations. This individual will play a critical role in managing efficient and collaborative cross-functional planning to support successful achievement of program and organizational goals. They will also have the opportunity to shape the growing Program Management function for the company.

Job Responsibilities

  • Support the management of cross-functional core teams and project teams that will include representatives from clinical, nonclinical, regulatory, CMC, and commercial, to create and execute integrated strategic development plans 
  • Build and maintain complex project plans and budgets from pre-clinical activities through launch and commercialization
  • Create and maintain program-related documentation, including, but not limited to, program plans and timelines, decision logs, risk management tools, monthly program updates, budget summaries and project goals, ensuring appropriate archiving and access
  • Manage team meeting operations such as planning agendas, scheduling meetings, preparing minutes, and proactively following-up with team members on critical action items
  • Partner with Program Team Leader to ensure effective and timely communication to team members and senior management regarding program deliverables, key milestones, achievement of external and internal commitments, timelines, budgets, and key events
  • Proactively identify risks; partners with scientific team to develop risk mitigation plans
  • Identify learnings and opportunities for synergies across the portfolio 
  • Support the growing Program and Portfolio Department by serving as the internal subject matter expert on program management best practices and implementing standardized processes to enable effective team function

Required Skills & Qualifications

  • 5-8 years of prior experience and training managing pre-clinical and clinical stage programs
  • BS/MS in a related scientific discipline, PhD a plus
  • Demonstrated proficiency and comfort with program management tools including the Microsoft Suite of products
  • Working knowledge of GXPs and other applicable compliance requirements
  • Expertise in creating and managing standard program management tools 
  • Proven track record of effective interpersonal and communication skills with ability to develop strong positive relationship with members of a multidisciplinary team including effective influencing skills.
  • Ability to operate effectively within an entrepreneurial and science-driven company environment
  • Good corporate and matrix management skills to meet Goldfinch Bio organizational needs and to leverage resources as required to drive assigned programs forward.
  • Exceptional listening, speaking and writing skills
  • High level of attention to detail
Senior Research Associate/Scientist, Biomarker Development Toggle

Job Summary

Goldfinch Bio seeks a highly motivated Senior Research Associate or Scientist with a strong background in molecular and cellular biology to join our biomarker group. In this lab-based position, the successful candidate will focus on the discovery and development of precision medicine biomarkers to support preclinical and clinical programs.

Job Responsibilities

  • Perform molecular and biochemical assays to measure biomarkers and enable data-driven decisions on program progression.
  • Maintain cell culture models and perform cell-based assays to characterize novel biomarkers.
  • Support assay development using new technologies.
  • Run ex vivo experiments including tissue processing and target engagement analysis.
  • Commit to helping the team achieve deliverables and meet aggressive timelines.
  • Maintenance of clear records of experimental work.

Required Skills & Qualifications

  • MS or PhD in biology or related discipline with 2+ years of relevant experience preferably in CRO / bio-pharmaceutical industry.
  • Hands-on experience with molecular biology techniques (PCR, RT-PCR, DNA/RNA isolation, SDS-PAGE, WB, ELISA, etc.) required.
  • Experience in cell culture, sterile technique and in vitro cellular assays required. Experience in kidney cell culture models would be advantageous. 
  • Ability to execute and analyze in vitro molecular biology experiments with minimal supervision.
  • Effective communication and organizational skills
  • Ability to proactively collaborate in cross-function teams.