At Goldfinch, we are pioneering a new approach to discover and develop precision medicines for kidney disease. Where others see risk, we see opportunity to make an impact and redefine the standard of care for patients with kidney disease. We recognize the importance of collaboration, and strive to work alongside people with kidney diseases, their families and clinicians to develop innovative treatments for conditions where no approved therapies exist.
We’re looking for teammates who relish the challenge, and are compelled to leave a positive mark on the lives of colleagues and the patients we serve alike. If this sounds like the community you want to grow with, we invite you to explore our current career opportunities below.
Scientist I/II, Biology Toggle
The Scientist I/II, Biology candidate should have strong image acquisition and image analysis skills across a variety of different systems and/or iPSC and organoid differentiation experience. They will develop, implement and execute in vitro assays required for the advancement of high priority projects and Goldfinch Bio's Product Engine. This position is part of a close-knit team focused on developing cutting edge assays for target validation and compound screening using in vitro models including human-derived kidney organoids.
Development and implementation of a diverse set of cellular assays used to support lead discovery and target validation with an emphasis on image-based assays
Develop image analysis methods and maintain imaging systems
Keep up with the literature and design, execute, troubleshoot, and interpret biological experiments in support of program objectives in partnership with scientific leadership
Contribute significantly to tissue culture work required for pipeline 2D and 3D cellular models
Interact and communicate results and conclusions to the biology team and cross-functional project teams
Required Skills & Qualifications
B.S. or M.S. in cell and/or molecular biology with minimum of 5 years of pharmaceutical/industry experience required OR Ph.D. with a minimum of 2 years experience
Significant experience in
confocal imaging, high-content imaging;
histological and immunofluorescence techniques
variety of image analysis methods (e.g. ImageJ/Fiji, Zen, Elements); familiarity with computational data analysis and/or Amira desirable but not required
Experience in cell and biochemical assay development and familiarity with high-throughput screens
Experience in biochemistry, molecular biology, and cell biology techniques
Extensive and diverse tissue culture experience; iPSC and organoid experience is desirable
Demonstrated ability to thrive in a team environment
We’re seeking a highly motivated Senior Scientist or Principal Scientist with a strong background in renal biology to join our Biology Department and contribute to building our pipeline for renal diseases. The successful candidate will focus on driving scientific research to establish and validate novel targets for kidney disease. Responsibilities include leading and mentoring a team of scientists, development, characterization and implementation of models of kidney disease based on human biology, and implementing models for evaluation of potential therapeutics.
Collaborate with scientists in cross-functional teams to discover tractable, high-impact disease targets.
Develop strategy and scientific approach to establish and characterize novel targets for kidney disease.
Establish in vitro assays to evaluate dose/response relationships, efficacy, and characterize molecules for potential therapeutic effects.
Initiate and manage external research collaborations to further the applications of in vitro models of chronic kidney disease.
Lead a group of researchers within Biology, providing guidance and mentorship.
Prepare, review and deliver high quality scientific presentations for internal/external use.
Commit to helping the team achieve deliverables and meet aggressive timelines.
Required Skills & Qualifications
PhD with at least 5 years post-degree research in the kidney disease field, translational experience is an asset. Prior work industry experience is an advantage but is not required.
Extensive hands-on experience with cell culture, in vitro and/or in vivo models of kidney disease.
Hands-on experience in cellular and biochemical techniques including standard molecular biology and protein biochemistry methods and proven assay troubleshooting skills.
Hands on experience in the development and validation of cell-based assays.
Experience with iPSCs and organoids is desirable.
Strong publication record and demonstrated experience conducting independent research.
Strong leadership and evidence of strategic scientific thinking.
Effective managerial skills and prior experience mentoring junior scientists with different skill sets.