A widespread disease
Chronic kidney disease (CKD) affects 780 million people globally. A condition of heterogenous origins, CKD is characterized by progressive loss of kidney function often leading to end-stage kidney disease, which significantly reduces quality of life.
Limited therapeutic options
Despite the widespread prevalence of CKD, there is no cure and there are no effective treatments for most forms of CKD. As a result, physicians are left to prescribe off-label therapies, which often lead patients to experience side effects that are more severe than the disease itself.
Because of the lack of disease-modifying treatments in kidney disease, patients typically continue to progress to end-stage kidney disease, leading to dialysis and/or transplantation.